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Drug Interactions between anacaulase topical and cilostazol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cilostazol anacaulase topical

Applies to: cilostazol and anacaulase topical

MONITOR: Concomitant use of anacaulase with anticoagulants or other drugs affecting coagulation may increase the risk of bleeding. According to the manufacturer, in vitro and animal data suggest that bromelain, a component of anacaulase-bcdb, can promote fibrinolysis. Reduced platelet aggregation and plasma fibrinogen levels and moderately increased partial thromboplastin and prothrombin times have also been reported following oral bromelain administration.

MANAGEMENT: Caution is advised if anacaulase is used in patients on anticoagulant therapy or other drugs affecting coagulation. Clinical and laboratory monitoring for coagulation abnormalities and bleeding is recommended.

References (1)
  1. (2022) "Product Information. Nexobrid (anacaulase topical)." Vericel Corporation

Drug and food interactions

Moderate

cilostazol food

Applies to: cilostazol

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of cilostazol. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

MANAGEMENT: Until more information is available, the manufacturer recommends avoiding consumption of grapefruit juice during cilostazol therapy. Orange juice is not expected to interact with cilostazol.

References (1)
  1. (2001) "Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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