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Drug Interactions between anacaulase topical and anagrelide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

anagrelide anacaulase topical

Applies to: anagrelide and anacaulase topical

MONITOR: Concomitant use of anacaulase with anticoagulants or other drugs affecting coagulation may increase the risk of bleeding. According to the manufacturer, in vitro and animal data suggest that bromelain, a component of anacaulase-bcdb, can promote fibrinolysis. Reduced platelet aggregation and plasma fibrinogen levels and moderately increased partial thromboplastin and prothrombin times have also been reported following oral bromelain administration.

MANAGEMENT: Caution is advised if anacaulase is used in patients on anticoagulant therapy or other drugs affecting coagulation. Clinical and laboratory monitoring for coagulation abnormalities and bleeding is recommended.

References (1)
  1. (2022) "Product Information. Nexobrid (anacaulase topical)." Vericel Corporation

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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