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Drug Interactions between amphotericin b liposomal and Vfend

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

amphotericin B liposomal voriconazole

Applies to: amphotericin b liposomal and Vfend (voriconazole)

Imidazole and triazole antifungal agents may antagonize the effects of amphotericin. The clinical significance is unknown. Caution is urged if combination therapy is necessary.

References

  1. Saag MS, Powderly WG, Cloud GA, et al. "Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis." N Engl J Med 326 (1992): 83-9
  2. "Product Information. Fungizone (amphotericin B)." Apothecon Inc (2022):
  3. "Product Information. Abelcet (amphotericin B lipid complex)." Liposome Company Inc, The
  4. "Product Information. Ambisome (amphotericin B liposomal)" Nexstar Pharmaceuticals, San Dimas, CA.
View all 4 references

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Drug and food interactions

Moderate

voriconazole food

Applies to: Vfend (voriconazole)

ADJUST DOSING INTERVAL: Food reduces the oral absorption and bioavailability of voriconazole. According to the product labeling, administration of multiple doses of voriconazole with high-fat meals decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 34% and 24%, respectively, when the drug is administered as a tablet, and by 58% and 37%, respectively, when administered as the oral suspension.

MANAGEMENT: To ensure maximal oral absorption, voriconazole tablets and oral suspension should be taken at least one hour before or after a meal.

References

  1. "Product Information. VFEND (voriconazole)." Pfizer U.S. Pharmaceuticals (2002):
  2. Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Antifungal agents

Therapeutic duplication

The recommended maximum number of medicines in the 'antifungal agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antifungal agents' category:

  • amphotericin b liposomal
  • Vfend (voriconazole)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer