Drug Interactions between amoxicillin / clarithromycin / lansoprazole and pexidartinib

Using pexidartinib together with clarithromycin is not recommended. Combining these medications may significantly increase the blood levels and side effects of pexidartinib. High blood levels of pexidartinib can cause serious side effects that may affect your liver. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor immediately if you experience an increase in side effects, including fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

By reducing the acidity level in the stomach, lansoprazole may interfere with the absorption of pexidartinib and reduce its effectiveness. Your doctor may be able to prescribe alternatives that do not interact or interact to a lesser extent and instruct you how to take these medicines. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Clarithromycin may increase the blood levels and side effects of lansoprazole in some people. Contact your doctor if you experience diarrhea or other intestinal problems. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Information for this minor interaction is available on the professional version.