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Drug Interactions between amoxicillin / clarithromycin / lansoprazole and eplerenone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

clarithromycin eplerenone

Applies to: amoxicillin / clarithromycin / lansoprazole and eplerenone

Using eplerenone together with clarithromycin is not recommended. Combining these medications may significantly increase the blood levels and effects of eplerenone. This can increase the risk of serious side effects including hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia during treatment with eplerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

clarithromycin lansoprazole

Applies to: amoxicillin / clarithromycin / lansoprazole and amoxicillin / clarithromycin / lansoprazole

Clarithromycin may increase the blood levels and side effects of lansoprazole in some people. Contact your doctor if you experience diarrhea or other intestinal problems. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

amoxicillin clarithromycin

Applies to: amoxicillin / clarithromycin / lansoprazole and amoxicillin / clarithromycin / lansoprazole

Information for this minor interaction is available on the professional version.

Drug and food interactions

Major

eplerenone food

Applies to: eplerenone

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with eplerenone as they may increase the blood levels and effects of eplerenone. High blood levels of eplerenone can increase the risk of side effects including hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia during treatment with eplerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

clarithromycin food

Applies to: amoxicillin / clarithromycin / lansoprazole

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer