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Drug interactions between amoxicillin / clarithromycin / lansoprazole and digoxin

Results for the following 2 drugs:
amoxicillin/clarithromycin/lansoprazole
digoxin

Interactions between your drugs

Major

clarithromycin ↔ digoxin

Applies to:amoxicillin/clarithromycin/lansoprazole and digoxin

Talk to your doctor before using digoxin together with clarithromycin. Combining these medications may significantly increase the blood levels and effects of digoxin. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

digoxin ↔ lansoprazole

Applies to:digoxin and amoxicillin/clarithromycin/lansoprazole

Talk to your doctor before using digoxin together with lansoprazole. Drugs known as proton pump inhibitors including lansoprazole may increase the effects of digoxin. In the short-term, lansoprazole can occasionally cause an increase in the blood levels of digoxin. You should seek immediate medical attention if you experience signs and symptoms that may indicate excessive effects of digoxin, such as nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. If you continue to take lansoprazole for a prolonged period (for example, several months to a year or more), you may develop a condition called hypomagnesemia, or low blood magnesium. Hypomagnesemia can increase the sensitivity of your heart to the effects of digoxin and cause toxicity even if your digoxin levels are within range. Let your doctor know if you develop symptoms of hypomagnesemia such as irregular heart rhythm, palpitations, muscle spasm, tremor, or seizures. In children, abnormal heart rhythm may cause fatigue, upset stomach, dizziness, and lightheadedness. If you are using an over-the-counter proton pump inhibitor medication such as Prilosec OTC, Zegerid OTC or Prevacid 24 HR, you should follow the directions on the package carefully. Do not use the medication more frequently or for a longer period than recommended on the label unless otherwise prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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