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Drug Interactions between ammonium lactate topical and calcipotriene topical

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

calcipotriene topical ammonium lactate topical

Applies to: calcipotriene topical and ammonium lactate topical

Coadministration with topical lactic acid may reduce the efficacy of calcipotriene. The mechanism of this interaction has not been fully investigated but may involve calcipotriene degradation in an acidic environment induced by acidic compounds or solutions. A study evaluating the compatibility of calcipotriene 0.005% ointment with other topical agents observed significant calcipotriene degradation at 24 hours when combined with ammonium lactate lotion 12%. Additionally, the same study also observed the combination of 6% salicylic acid with calcipotriene 0.005% ointment led to an unstable mixture, resulting in complete calcipotriene degradation within 6 hours. Guidelines for the management of psoriasis and psoriatic arthritis recommend that calcipotriene should not be used concurrently with products that can alter the pH of its base. However, if multiple topical agents are required, patients should be instructed to apply medications at different times throughout the day.

References (2)
  1. patel b, siskin s, krazmien r, Lebwohl M (1998) "Compatibility of calcipotriene with other topical medications." J Am Acad Dermatol, 38, p. 1010-1
  2. Menter A, korman nj, elmets ca, et al. (2009) "Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies." J Am Acad Dermatol, 60, p. 643-59

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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