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Drug Interactions between amiodarone and sofosbuvir

This report displays the potential drug interactions for the following 2 drugs:

  • amiodarone
  • sofosbuvir

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Interactions between your drugs


amiodarone sofosbuvir

Applies to: amiodarone and sofosbuvir

Using amiodarone together with sofosbuvir can cause excessive slowing of your heart rate that can lead to serious or life-threatening cardiac complications. This is most likely to occur early on after you start treatment with these medications, especially within the first 48 hours. It may be alright for you to receive both medications; however, treatment should be initiated under close medical supervision. Your first dose of medication must be taken at your doctor's office or in a hospital where they can monitor your heart rate, and you will need to have your heart rate monitored every day for at least the first 2 weeks of treatment. Contact your doctor if you develop dizziness, lightheadedness, fainting, shortness of breath, confusion, weakness, excessive tiredness, chest pain, or heart palpitations at any time during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


amiodarone food

Applies to: amiodarone

Amiodarone may be taken with or without food but should be taken at the same way each time. You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Grapefruit can raise the levels of amiodarone in your body and lead to dangerous side effects. This can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.