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Drug Interactions between aminophylline and moricizine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

moricizine aminophylline

Applies to: moricizine and aminophylline

Moricizine may increase the plasma clearance of theophylline by 46% to 68% and decrease theophylline half-life by 20% to 34%. Decreased plasma theophylline levels may result. Conversely, theophylline toxicity may occur when moricizine is discontinued. The mechanism is unknown, but may be related to hepatic enzyme induction. Management consists of monitoring the patient for theophylline efficacy, checking levels if indicated, and adjusting theophylline dosage accordingly. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms.

References (3)
  1. Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet, 20, p. 135-50
  2. Siddoway LA, Schwartz SL, Barbey JT, Woosley RL (1990) "Clinical pharmacokinetics of moricizine." Am J Cardiol, 65, d21-5; disc. D68-71
  3. Pieniaszek HJ Jr, Davidson AF, Benedek IH (1993) "Effect of moricizine on the pharmacokinetics of single-dose theophylline in healthy subjects." Ther Drug Monit, 15, p. 199-203

Drug and food interactions

Moderate

aminophylline food

Applies to: aminophylline

MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.

MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.

References (7)
  1. Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
  2. Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
  3. (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
  4. (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
  5. (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
  6. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  7. (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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