Drug Interactions between aminophylline / ephedrine / guaifenesin / phenobarbital and landiolol

Consumer information for this interaction is not currently available.

MONITOR CLOSELY: Coadministration of landiolol with positive inotropes, vasoconstrictors, or sympathomimetic agents may decrease the therapeutic effects of landiolol. According to the package labeling, concomitant use reduced landiolol's heart rate and blood pressure lowering effects. In addition, concomitant dobutamine also reduced landiolol's effect on PR-interval prolongation.

MANAGEMENT: If coadministration is clinically necessary, careful titration of the landiolol infusion and close hemodynamic monitoring is advised. Consultation with package labeling and relevant institutional protocols may be advisable for further guidance.

Consumer information for this interaction is not currently available.

GENERALLY AVOID: The pharmacologic effects of theophyllines and beta-blockers are opposite. Nonselective and high doses of cardioselective beta-blockers may cause severe or fatal bronchospasm by opposing theophylline-induced bronchodilation. Ophthalmic beta-blockers undergo significant systemic absorption and may also interact. In addition, propranolol and other beta-blockers may reduce the CYP450 hepatic metabolism of theophylline, and serum theophylline levels may be increased.

MANAGEMENT: Oral and ophthalmic nonselective beta-blockers (e.g., carteolol, carvedilol, levobunolol, metipranolol, nadolol, oxprenolol, penbutolol, pindolol, propranolol, sotalol, and timolol) are considered contraindicated in patients with bronchospastic diseases. Cardioselective beta-blockers should generally be avoided, or used with extreme caution if no other alternatives are available and the benefits outweigh the risks of potentially severe bronchospasm. If patients do receive this combination, they should be closely monitored for increased serum theophylline levels but decreased bronchodilatory effectiveness.

Using PHENobarbital together with aminophylline may decrease the effects of aminophylline. Contact your doctor if your condition changes or if you experience breathing difficulties. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumer information for this interaction is not currently available.

MONITOR: Concomitant use of landiolol with barbiturates may result in additive blood pressure lowering effects. Landiolol alone is associated with increased risk of hypotension, and therefore coadministration of these agents may potentiate these effects.

MANAGEMENT: Concomitant use of landiolol with barbiturates should be done with caution. If coadministration is clinically necessary, careful titration of the landiolol infusion and close hemodynamic monitoring is advised. Consultation with package labeling and relevant institutional protocols may be advisable for further guidance.

Information for this minor interaction is available on the professional version.