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Drug Interactions between aminoglutethimide and Predcor

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

prednisoLONE aminoglutethimide

Applies to: Predcor (prednisolone) and aminoglutethimide

MONITOR: Coadministration with aminoglutethimide may decrease the plasma concentrations of corticosteroids. The proposed mechanism is induction of CYP450 3A4-mediated metabolism by aminoglutethimide.

MANAGEMENT: Patients should be monitored for altered corticosteroid efficacy following the initiation and discontinuation of aminoglutethimide, and the dosage adjusted accordingly to achieve desired clinical effect. If glucocorticoid replacement is necessary, hydrocortisone may be a suitable agent because it does not appear to interact.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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