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Drug Interactions between aminoglutethimide and Dexamethasone Intensol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dexAMETHasone aminoglutethimide

Applies to: Dexamethasone Intensol (dexamethasone) and aminoglutethimide

GENERALLY AVOID: Aminoglutethimide may significantly increase dexamethasone clearance by induction of CYP450 3A4 hepatic microsomal enzymes. An increase of 292% in dexamethasone clearance has been reported. It is unknown whether other corticosteroids would be affected to the same extent.

MANAGEMENT: Dexamethasone should not be used in patients receiving aminoglutethimide for adrenal suppression. If glucocorticoid replacement is necessary, hydrocortisone is recommended as an alternative because it does not appear to interact.

References (2)
  1. Kvinssland S, Lonning PE, Ueland PM (1986) "Aminoglutethimide as an inducer of microsomal enzymes. Part 1: Pharmacological aspects." Breast Cancer Res Treat, 7, s73-6
  2. (2002) "Product Information. Cytadren (aminoglutethimide)." Ciba Self-Medication Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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