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Drug Interactions between aminoglutethimide and Brondelate

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

aminoglutethimide oxtriphylline

Applies to: aminoglutethimide and Brondelate (guaifenesin / oxtriphylline)

MONITOR: Aminoglutethimide may significantly reduce theophylline serum concentrations by increasing theophylline clearance. The mechanism is induction of CYP450 3A4 hepatic microsomal enzymes. One study noted an increase of 32% in theophylline clearance. Conversely, theophylline toxicity may occur after aminoglutethimide is discontinued.

MANAGEMENT: The patient should be monitored for clinical and laboratory evidence of altered theophylline response when aminoglutethimide is added, discontinued, or the dosage is changed. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms during concurrent therapy.

References

  1. Lonning PE, Kvinnsland S, Bakke OM (1984) "Effect of aminoglutethimide on antipyrine, theophylline, and digitoxin disposition in breast cancer." Clin Pharmacol Ther, 36, p. 796-802

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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