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Drug Interactions between Amikin Pediatric and Timentin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amikacin ticarcillin

Applies to: Amikin Pediatric (amikacin) and Timentin (clavulanate / ticarcillin)

ADJUST DOSING INTERVAL: Ticarcillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is significant only in patients with renal failure or if the agents are mixed in the same IV container or line. Lower serum aminoglycoside levels may be seen, and dosage adjustments may be necessary.

MANAGEMENT: Ticarcillin and aminoglycosides should be administered separately during combined therapy.

References

  1. Riff LJ, Jackson GG (1972) "Laboratory and clinical conditions for gentamicin inactivation by carbenicillin." Arch Intern Med, 130, p. 887-91
  2. Davies M, Morgan JR, Anand C (1975) "Interactions of carbenicillin and ticarcillin with gentamicin." Antimicrob Agents Chemother, 7, p. 431-4
  3. Thompson MI, Russo ME, Saxon BJ, Atkin-Thor E, Matsen JM (1982) "Gentamicin inactivation by piperacillin or carbenicillin in patients with end-stage renal disease." Antimicrob Agents Chemother, 21, p. 268-72
  4. Konishi H, Goto M, Nakamoto Y, Yamamoto I, Yamashina H (1983) "Tobramycin inactivation by carbenicillin, ticarcillin, and piperacillin." Antimicrob Agents Chemother, 23, p. 653-7
  5. Halstenson CE, Hirata CA, Heim-Duthoy KL, Abraham PA, Matzke GR (1990) "Effect of concomitant administration of piperacillin on the dispositions of netilmicin and tobramycin in patients with end-stage renal disease." Antimicrob Agents Chemother, 34, p. 128-33
  6. Polk RE, Kline BJ (1980) "Mail order tobramycin serum levels: low values caused by ticarcillin." Am J Hosp Pharm, 37, 920, 922
  7. Kradjan WA, Burger R (1980) "In vivo inactivation of gentamycin by carbenicillin and ticarcillin." Arch Intern Med, 140, p. 1668-70
  8. Russo ME, Atkin-Thor E (1981) "Gentamicin and ticarcillin in subjects with end-stage renal disease." Clin Nephrol, 15, p. 175-80
  9. Matzke GR, Luckham DR, Collins AJ, Halstenson CE (1984) "Effect of ticarcillin on gentamicin and tobramycin pharmacokinetics in a patient with end-stage renal disease." Pharmacotherapy, 4, p. 158-60
  10. Viollier AF, Standiford HC, Drusano GL, Tatem BA, Moody MR, Schimpff SC (1985) "Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin." J Antimicrob Chemother, 15, p. 597-606
  11. Weibert R, Keane W, Shapiro F (1976) "Carbenicillin inactivation of aminoglycosides in patients with severe renal failure." Trans Am Soc Artif Intern Organs, 22, p. 439-43
  12. Russo ME (1980) "Penicillin-aminoglycoside inactivation: another possible mechanism of interaction." Am J Hosp Pharm, 37, p. 702-4
  13. Konishi H, Goto M, Nakamoto Y, Yamamoto I, Yamashina H (1983) "Tobramycin inactivation by carbenicillin, ticaracillin, and piperacillin." Antimicrob Agents Chemother, 23, p. 653-7
  14. Pickering LK, Rutherford I (1981) "Effect of concentration and time upon inactivation of tobramycin, gentamicin, netilmicin and amikacin by azlocillin, carbenicillin, mecillinam, mezlocillin and piperacillin." J Pharmacol Exp Ther, 217, p. 345-9
  15. Henderson JL, Polk RE, Kline BJ (1981) "In vitro inactivation of gentamicin, tobramycin, and netilmicin by carbenicillin, azlocillin, or mezlocillin." Am J Hosp Pharm, 38, p. 1167-70
  16. (2018) "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated
View all 16 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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