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Drug Interactions between amifampridine and methacholine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methacholine amifampridine

Applies to: methacholine and amifampridine

MONITOR: Coadministration of amifampridine with direct or indirect cholinesterase inhibitors may result in additive cholinergic effects and increased adverse reactions such as nausea, diarrhea, abdominal pain, muscle weakness, dizziness, drowsiness, and seizures. Amifampridine may produce cholinergic effects by facilitating the release of acetylcholine from nerve endings and enhancing neuromuscular transmission.

MANAGEMENT: Patients should be apprised of the potential for increased cholinergic effects when amifampridine is coadministered with other drugs that have cholinergic effects such as cholinesterase inhibitors.

References (2)
  1. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
  2. (2018) "Product Information. Firdapse (amifampridine)." Catalyst Pharmaceuticals, Inc.

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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