Can you take Alprostadil with Sepiapterin?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- alprostadil
- sepiapterin
Drug interactions
Moderate drug interactions
Moderate:
alprostadil sepiapterin
Applies to: alprostadil and sepiapterin
Using sepiapterin together with alprostadil may lower your blood pressure and increase the risk of:
- dizziness
- weakness
- headache
- flushing
- fainting
These side effects are most likely to be seen at the beginning of treatment with sepiapterin, following a dose increase, or when treatment is restarted after an interruption.
Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome.
Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
sepiapterin Food/Lifestyle
Applies to: sepiapterin
Food helps to increase the absorption of sepiapterin.
To ensure adequate blood levels, sepiapterin should be given with food. Additional food should be also consumed after the dose of sepiapterin is taken.
Moderate:
alprostadil Alcohol (Ethanol)
Applies to: alprostadil
Alprostadil and ethanol (alcohol) may have additive effects in lowering your blood pressure.
You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted.
Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness.
Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
6 potential interactions Applies to: 6 conditions, including Hypotension, Liver Disease, Sepsis, Renal Dysfunction, and Bleeding Associated with Coagulation Defect.
Bleeding Associated with Coagulation Defect
Moderate:
alprostadil
Alprostadil has a moderate potential interaction with Bleeding Associated with Coagulation Defect.
Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.
Hypotension
Moderate:
alprostadil
Alprostadil has a moderate potential interaction with Hypotension.
Increased peripheral blood levels of prostaglandin E1 (PGE1) and its metabolites can lead to hypotension and/or dizziness. Intracavernous injections of alprostadil can lead to increased blood levels of PGE1. Therapy with alprostadil should be administered cautiously in patients with hypotension.
Liver Disease
Moderate:
sepiapterin
Sepiapterin has a moderate potential interaction with Liver Disease.
The effect of renal or liver dysfunction on the pharmacokinetics of sepiapterin or the active metabolite tetrahydrobiopterin (BH4) is unknown.
Pulmonary Impairment
Major:
alprostadil
Alprostadil has a major potential interaction with Pulmonary Impairment.
Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.
Renal Dysfunction
Moderate:
sepiapterin
Sepiapterin has a moderate potential interaction with Renal Dysfunction.
The effect of renal or liver dysfunction on the pharmacokinetics of sepiapterin or the active metabolite tetrahydrobiopterin (BH4) is unknown.
Sepsis
Major:
alprostadil
Alprostadil has a major potential interaction with Sepsis.
Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.
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More resources
alprostadil
A total of 420 drugs are known to interact with alprostadil.
- Alprostadil is in the following drug classes: Erectile Dysfunction (ED) Treatments, vasodilators.
- Alprostadil is used to treat the following conditions:
sepiapterin
A total of 38 drugs are known to interact with sepiapterin.
- Sepiapterin is in the drug class miscellaneous metabolic agents.
- Sepiapterin is used to treat Phenylketonuria.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.