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Drug Interactions between alosetron and viloxazine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

alosetron viloxazine

Applies to: alosetron and viloxazine

CONTRAINDICATED: Coadministration of viloxazine, a potent inhibitor of CYP450 1A2, may significantly increase the risk of adverse reactions to sensitive CYP450 1A2 substrates or CYP450 1A2 substrates with a narrow therapeutic range. According to the prescribing information, viloxazine increased the systemic exposure (AUC) of caffeine, a probe CYP450 1A2 substrate, by nearly 6-fold without affecting its peak plasma concentration (Cmax).

MANAGEMENT: Concomitant use of viloxazine with sensitive CYP450 1A2 substrates or CYP450 1A2 substrates with a narrow therapeutic range such as alosetron, duloxetine, ramelteon, tasimelteon, tizanidine, or theophylline is contraindicated.

References (1)
  1. (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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