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Drug Interactions between alosetron and Pronestyl

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

procainamide alosetron

Applies to: Pronestyl (procainamide) and alosetron

Theoretically, coadministration with alosetron may increase the plasma concentrations of drugs that undergo metabolism by N-acetyltransferase such as hydralazine, isoniazid, and procainamide. In an in vivo metabolic probe study, alosetron produced 30% inhibition of N-acetyltransferase. However, concomitant administration of alosetron with substrates of N-acetyltransferase has not been evaluated, and the clinical significance of such an interaction is unknown.

References (1)
  1. (2001) "Product Information. Lotronex (alosetron)." Glaxo Wellcome

Drug and food interactions

Minor

procainamide food

Applies to: Pronestyl (procainamide)

Ethanol may increase the acetylation of procainamide. Subtherapeutic plasma levels of procainamide may result in some patients. Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.

References (1)
  1. Olsen H, Morland J (1982) "Ethanol-induced increase in procainamide acetylation in man." Br J Clin Pharmacol, 13, p. 203-8

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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