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Drug Interactions between aloe vera and pramlintide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

pramlintide aloe vera

Applies to: pramlintide and aloe vera

MONITOR: Concomitant use of oral products containing aloe vera gel may potentiate the hypoglycemic effect of insulin and other antidiabetic agents. Aloe vera has demonstrated hypoglycemic effects in streptozotocin-induced diabetes in rats, and limited data in diabetic patients have indicated efficacy in reducing blood glucose when used alone or in combination with oral hypoglycemic agents.

MANAGEMENT: Until more data are available, caution is advised when aloe vera is administered orally to patients receiving insulin or other antidiabetic agents due to the potential for increased risk of hypoglycemia. Patients should be monitored for changes in diabetic medication requirements.

References (3)
  1. Tanaka M, Misawa E, Yousuke I, et al. (2006) "Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds." Biol Pharm Bull, 29, p. 1418-22
  2. Vogller BK (1999) "Aloe vera: a systematic review of its clinical effectiveness." Br J Gen Pract, 49, p. 823-8
  3. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS (2003) "Systemic review of herbs and dietary supplements for glycemic control in diabetes." Diabetes Care, 26, p. 1277-94

Drug and food interactions

Moderate

pramlintide food

Applies to: pramlintide

ADJUST DOSING INTERVAL: Pramlintide slows gastric emptying and may delay the absorption of concomitantly administered oral medications. In a pharmacokinetic study of 24 patients with type 2 diabetes, coadministration with pramlintide (120 mcg) decreased the peak plasma concentration (Cmax) of acetaminophen (1000 mg) by 29% and increased its time to peak plasma concentration (Tmax) based on the time of acetaminophen administration relative to pramlintide injection. Pramlintide significantly increased acetaminophen Tmax (range 48 to 72 minutes) when acetaminophen was administered simultaneously with or up to 2 hours following pramlintide injection, but it had negligible effect when acetaminophen was administered 1 to 2 hours before pramlintide injection.

MANAGEMENT: When rapid onset of a concomitantly administered oral medication is critical to its effectiveness, the medication should be administered at least 1 hour before or 2 hours after pramlintide injection.

References (1)
  1. (2005) "Product Information. Symlin (pramlintide)." Amphastar Pharmaceuticals Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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