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Drug Interactions between aloe vera and exenatide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

exenatide aloe vera

Applies to: exenatide and aloe vera

MONITOR: Concomitant use of oral products containing aloe vera gel may potentiate the hypoglycemic effect of insulin and other antidiabetic agents. Aloe vera has demonstrated hypoglycemic effects in streptozotocin-induced diabetes in rats, and limited data in diabetic patients have indicated efficacy in reducing blood glucose when used alone or in combination with oral hypoglycemic agents.

MANAGEMENT: Until more data are available, caution is advised when aloe vera is administered orally to patients receiving insulin or other antidiabetic agents due to the potential for increased risk of hypoglycemia. Patients should be monitored for changes in diabetic medication requirements.

References (3)
  1. Tanaka M, Misawa E, Yousuke I, et al. (2006) "Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds." Biol Pharm Bull, 29, p. 1418-22
  2. Vogller BK (1999) "Aloe vera: a systematic review of its clinical effectiveness." Br J Gen Pract, 49, p. 823-8
  3. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS (2003) "Systemic review of herbs and dietary supplements for glycemic control in diabetes." Diabetes Care, 26, p. 1277-94

Drug and food interactions

Moderate

exenatide food

Applies to: exenatide

ADJUST DOSING INTERVAL: Exenatide slows gastric emptying and may reduce the extent and rate of absorption of concomitantly administered oral medications. When acetaminophen 1000 mg was administered simultaneously with exenatide 10 mcg and also one hour, 2 hours, and 4 hours after exenatide injection, acetaminophen systemic exposure (AUC) was decreased by 21%, 23%, 24%, and 14%, respectively; peak plasma concentration (Cmax) was decreased by 37%, 56%, 54%, and 41%, respectively; and time to peak plasma concentration (Tmax) was increased from 0.6 hours in the control period to 0.9 hours, 4.2 hours, 3.3 hours, and 1.6 hours, respectively. These values were not significantly changed when acetaminophen was given one hour before exenatide injection.

MANAGEMENT: Concomitantly administered oral medications that are dependent on threshold concentrations for efficacy (e.g., antibiotics, contraceptives) or that require rapid gastrointestinal absorption (e.g., hypnotics, pain medications) should be administered at least 1 hour before exenatide. If such medications are to be administered with food, patients should be advised to take them with a meal or snack when exenatide is not administered.

References (1)
  1. (2005) "Product Information. Byetta (exenatide)." Amylin Pharmaceuticals Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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