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Drug Interactions between allopurinol and Treanda

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

allopurinol bendamustine

Applies to: allopurinol and Treanda (bendamustine)

MONITOR: Coadministration of bendamustine with allopurinol may increase the risk of severe skin reactions. Rare cases of Stevens-Johnson syndrome and toxic epidermal necrolysis, some fatal, have been reported when bendamustine was administered concomitantly with allopurinol and other medications known to be associated with these toxicities. The potential mechanism of interaction has not been established.

MANAGEMENT: Although allopurinol may be given to prevent tumor lysis syndrome during treatment with bendamustine, caution is advised when these medications are used together. Because skin reactions may be progressive and increase in severity with further treatment, patients who develop skin reactions should be closely monitored. The manufacturer recommends that bendamustine be withheld or discontinued if skin reactions are severe or progressive.

References (2)
  1. (2008) "Product Information. Treanda (bendamustine)." Cephalon Inc
  2. (2016) "Product Information. Bendeka (bendamustine)." Teva Pharmaceuticals USA

Drug and food interactions

Moderate

allopurinol food

Applies to: allopurinol

ADJUST DOSING INTERVAL: The tolerability of allopurinol may be improved by giving it after a meal. Additionally, when the dose is greater than 300 mg, dividing the total daily dose into smaller doses administered more often may be appropriate to help minimize gastrointestinal irritation.

MONITOR: Concomitant use of allopurinol with central nervous system (CNS) depressants, including alcohol, may potentiate adverse effects such as somnolence and sedation.

MANAGEMENT: To improve tolerability, some manufacturers suggest administering allopurinol after a meal. Additionally, if the daily dose is greater than 300 mg, administering allopurinol in divided doses may help reduce gastrointestinal intolerance. Patients should also be counseled to avoid or limit consumption of alcohol and to avoid activities requiring mental alertness such as driving or operating hazardous machinery until they know how the medication affects them.

References (4)
  1. (2024) "Product Information. Allopurinol (Sandoz) (allopurinol)." Sandoz Pty Ltd
  2. (2021) "Product Information. Zyloric (allopurinol)." Aspen Pharma Trading Ltd
  3. (2021) "Product Information. Zyloprim (allopurinol)." AA Pharma Inc, 248178
  4. (2024) "Product Information. Allopurinol (allopurinol)." Actavis U.S. (Purepac Pharmaceutical Company)

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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