Drug Interactions between allopurinol / lesinurad and capecitabine
This report displays the potential drug interactions for the following 2 drugs:
- allopurinol/lesinurad
- capecitabine
Interactions between your drugs
allopurinol capecitabine
Applies to: allopurinol / lesinurad and capecitabine
GENERALLY AVOID: In vitro and nonclinical data suggest that allopurinol may suppress phosphorylation of fluorouracil to its active metabolites and reduce its anti-tumor activity. However, published studies have reported conflicting and inconsistent results regarding the capacity of allopurinol to clinically modulate anti-tumor efficacy and toxicity of fluorouracil.
MANAGEMENT: The clinical significance of this potential interaction has not been fully characterized. Concomitant use of fluorouracil or its prodrugs (e.g., capecitabine) with allopurinol should generally be avoided.
References
- (2022) "Product Information. Aloprim (allopurinol)." Mylan Institutional (formally Bioniche Pharma USA Inc)
- (2021) "Product Information. Xeloda (capecitabine)." Genentech
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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