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Drug interactions between Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula) and metoprolol

Results for the following 2 drugs:
Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula) (acetaminophen/dextromethorphan/doxylamine/phenylephrine)
metoprolol

Interactions between your drugs

Moderate

metoprolol phenylephrine

Applies to: metoprolol and Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula) (acetaminophen / dextromethorphan / doxylamine / phenylephrine)

Using phenylephrine together with a beta-blocker like metoprolol may lead to an increase in blood pressure. Some beta-blockers may enhance the effects of phenylephrine, which can lead to constriction of your blood vessels and an increase in blood pressure. Contact your doctor if your condition changes. You may need a dose adjustment or your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

metoprolol food

Applies to: metoprolol

Food can enhance the levels of metoprolol in your body. You should take metoprolol at the same time each day, preferably with or immediately following meals. This will make it easier for your body to absorb the medication. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking metoprolol. Metoprolol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

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Moderate

doxylamine food

Applies to: Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula) (acetaminophen / dextromethorphan / doxylamine / phenylephrine)

Alcohol can increase the nervous system side effects of doxylamine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with doxylamine. Do not use more than the recommended dose of doxylamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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