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Drug Interactions between alfentanil and oritavancin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ALfentanil oritavancin

Applies to: alfentanil and oritavancin

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of alfentanil, which appears to be extensively metabolized by the isoenzyme. Clinical data are limited, however. In nine healthy male volunteers, intravenous administration of a single 20 mcg/kg dose of alfentanil with the potent CYP450 3A4 inducer rifampin increased alfentanil clearance by nearly 3-fold and decreased elimination half-life by 40% compared to controls. Another study also reported substantially increased clearance rates of alfentanil in seven patients receiving long-term therapy with inducer drugs compared to six patients not receiving those drugs (mean clearance 6.94 mL/min/kg vs. 3.47 mL/min/kg; half-life 50.6 hrs vs. 90.7 hrs).

MANAGEMENT: Patients who are currently receiving or have recently received drugs that induce CYP450 3A4 should be monitored for potentially decreased response to alfentanil, and the dosage adjusted as necessary.

Drug and food interactions

Moderate

ALfentanil food

Applies to: alfentanil

Do not use alcohol or medications that contain alcohol while you are receiving treatment with ALfentanil. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of alcohol may also cause rapid release of the drug, resulting in high blood levels that may be potentially lethal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of ALfentanil, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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