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Drug Interactions between Afluria Quadrivalent and fosphenytoin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

influenza virus vaccine, inactivated fosphenytoin

Applies to: Afluria Quadrivalent (influenza virus vaccine, inactivated) and fosphenytoin

MONITOR: Influenza virus vaccine has been reported to exert a variety of effects on phenytoin pharmacokinetics. Both decreases and increases in phenytoin serum concentrations have both been reported. The mechanism is unknown.

MANAGEMENT: Close observation for clinical and laboratory evidence of altered phenytoin effect is recommended for at least 2 weeks after influenza virus vaccine is administered to a patient receiving phenytoin. Patients should be advised to notify their physician if they experience loss of seizure control or symptoms of phenytoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).

References (4)
  1. Sawchuk RJ, Rector TS, Fordice JJ, Leppik IE (1979) "Effect of influenza vaccination on plasma phenytoin concentrations." Ther Drug Monit, 1, p. 285-8
  2. Jann MW, Fidone GS (1986) "Effect of influenza vaccine on serum anticonvulsant concentrations." Clin Pharm, 5, p. 817-20
  3. Smith CD, Bledsoe MA, Curran R, Green L, Lewis J (1988) "Effect of influenza vaccine on serum concentrations of total and free phenytoin." Clin Pharm, 7, p. 828-32
  4. Grabenstein JD (1990) "Drug interactions involving immunologic agents. Part II. Immunodiagnostic and other immunologic drug interactions." DICP, 24, p. 186-93

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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