Skip to main content

Drug Interactions between Afluria Preservative-Free Pediatric Quadrivalent and oxtriphylline

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Minor

oxtriphylline influenza virus vaccine, inactivated

Applies to: oxtriphylline and Afluria Preservative-Free Pediatric Quadrivalent (influenza virus vaccine, inactivated)

Limited data suggest that administration of split, trivalent influenza vaccine may cause a transient reduction in theophylline clearance. However, further studies have not been able to reproduce this interaction. Patients should be monitored for possible theophylline toxicity following influenza vaccination. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.

References (8)
  1. Renton KW, Gray JD, Hall RI (1980) "Decreased elimination of theophylline after influenza vaccination." Can Med Assoc J, 123, p. 288-90
  2. Bukowskyj M, Munt PW, Wigle R, Nakatsu K (1984) "Theophylline clearance: lack of effect of influenza vaccination and ascorbic acid." Am Rev Respir Dis, 129, p. 672-5
  3. Patriarca PA, Kendal AP, Stricof RL, Weber JA, Meissner MK, Dateno B (1983) "Influenza vaccination and warfarin or theophylline toxicity in nursing home patients." N Engl J Med, 308, p. 1601-2
  4. Meredith CG, Christian CD, Johnson RF, Troxell R, Davis GL, Schenker S (1985) "Effects of influenza virus vaccine on hepatic drug metabolism." Clin Pharmacol Ther, 37, p. 396-401
  5. Winstanley PA, Tjia J, Back DJ, Hobson D, Breckenridge AM (1985) "Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism." Br J Clin Pharmacol, 20, p. 47-53
  6. Gomolin IH, Chapron DJ, Luhan PA (1985) "Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly." J Am Geriatr Soc, 33, p. 269-72
  7. Grabowski N, May JJ, Pratt DS, Richtsmeier WJ, Bertino Jr JS (1985) "The effect of split virus influenza vaccination on theophylline pharmacokinetics." Am Rev Respir Dis, 131, p. 934-8
  8. Jonkman JHG, Wymenga ASC, de Zeeuw RA, et al. (1988) "No effect of influenza vaccination on theophylline pharmacokinetics as studied by ultraviolet spectrophotometry, HPLC, and EMIT assay methods." Ther Drug Monit, 10, p. 345-48

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer