Can you take Aflexeryl-MC with Zuranolone?

Coadministration with orally administered menthol may decrease plasma concentrations of drugs that are substrates of the CYP450 3A4 and/or CYP450 2C9 isoenzymes. The proposed mechanism is increased clearance due to menthol-mediated induction of CYP450 3A4 and CYP450 2C9. In vivo data suggests that concomitant administration of oral menthol reduced the systemic exposure (AUC) of triazolam (a CYP450 3A4 substrate) by 40%, and phenytoin (a CYP450 2C9 substrate) by 20%. Until further data are available, no specific precautions are recommended.

The information above is from our professional interaction data. Consumer information is not available for this interaction.

Zuranolone must be taken with fat-containing food to ensure adequate absorption of the medication.

It is also best to avoid or limit the consumption of alcohol, as it can increase drowsiness or other nervous system side effects of zuranolone.

You should also avoid activities requiring mental alertness such as driving or operating hazardous machinery until at least 12 hours after taking zuranolone.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.