Drug Interactions between Advil Allergy Sinus and fluconazole
This report displays the potential drug interactions for the following 2 drugs:
- Advil Allergy Sinus (chlorpheniramine/ibuprofen/pseudoephedrine)
- fluconazole
Interactions between your drugs
ibuprofen fluconazole
Applies to: Advil Allergy Sinus (chlorpheniramine / ibuprofen / pseudoephedrine) and fluconazole
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with fluconazole may alter the plasma concentrations of naproxen and its pharmacologically active metabolite. The proposed mechanism is the fluconazole mediated inhibition of the metabolism of naproxen via CYP450 2C9. The interaction may extend to other nonsteroidal anti-inflammatory drugs (NSAIDs) such as meloxicam, lornoxicam, and diclofenac. However, clinical data evaluating this interaction for all the abovementioned nonsteroidal anti-inflammatory drugs are not available.
MANAGEMENT: Caution is recommended with the concomitant use of NSAIDs with fluconazole. It may be advisable to monitor the pharmacologic response to the NSAID and its adverse effects more closely whenever fluconazole is added to or withdrawn from therapy. Patients should be advised to report possible signs of NSAID-related toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools.
Drug and food/lifestyle interactions
chlorpheniramine food/lifestyle
Applies to: Advil Allergy Sinus (chlorpheniramine / ibuprofen / pseudoephedrine)
Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
ibuprofen food/lifestyle
Applies to: Advil Allergy Sinus (chlorpheniramine / ibuprofen / pseudoephedrine)
Ask your doctor before using ibuprofen together with ethanol (alcohol). Do not drink alcohol while taking ibuprofen. Alcohol can increase your risk of stomach bleeding caused by ibuprofen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
pseudoephedrine food/lifestyle
Applies to: Advil Allergy Sinus (chlorpheniramine / ibuprofen / pseudoephedrine)
Both pseudoephedrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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