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Drug Interactions between Adriamycin RDF and bleomycin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

bleomycin DOXOrubicin

Applies to: bleomycin and Adriamycin RDF (doxorubicin)

MONITOR: The concomitant or sequential administration of multiple antineoplastic agents may result in additive toxicities, particularly in the bone marrow, gastrointestinal tract and heart.

MANAGEMENT: Close clinical and laboratory monitoring for hematologic and nonhematologic toxicities are recommended when antineoplastic agents are administered concurrently or during close intervals. Dosing adjustments may be necessary. The manufacturers' recommendations and institutional protocols for dosage, treatment regimens, monitoring, and management of toxicities should be consulted.

References (9)
  1. (2001) "Product Information. Paraplatin (carboplatin)." Bristol-Myers Squibb
  2. (2001) "Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb
  3. (2022) "Product Information. Fluorouracil (fluorouracil)." Roche Laboratories
  4. (2001) "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn
  5. (2001) "Product Information. Ellence (epirubicin)." Pharmacia and Upjohn
  6. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  7. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
  8. Cerner Multum, Inc. "Australian Product Information."
  9. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Antineoplastic antibiotics

Therapeutic duplication

The recommended maximum number of medicines in the 'antineoplastic antibiotics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antineoplastic antibiotics' category:

  • Adriamycin RDF (doxorubicin)
  • bleomycin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer