Drug Interactions between Adrenocot LA and apixaban
This report displays the potential drug interactions for the following 2 drugs:
- Adrenocot LA (dexamethasone)
- apixaban
Interactions between your drugs
dexAMETHasone apixaban
Applies to: Adrenocot LA (dexamethasone) and apixaban
MONITOR: Coadministration with inducers of CYP450 3A4 and/or P-glycoprotein (P-gp) may decrease the plasma concentrations of apixaban, which is a substrate of both the isoenzyme and the efflux transporter. When apixaban was coadministered with 600 mg/day of rifampin, a dual P-gp and potent CYP450 3A4 inducer, mean apixaban peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 42% and 54%, respectively. No data are available for use with other, less potent CYP450 3A4 or P-gp inducers.
MANAGEMENT: The potential for diminished pharmacologic effects of apixaban should be considered during coadministration with inducers of CYP450 3A4 and/or P-gp. Alternative treatments may be required if an interaction is suspected.
References
- (2012) "Product Information. Eliquis (apixaban)." Bristol-Myers Squibb Canada Inc
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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