Drug Interactions between Addyi and trientine

Do not use alcohol too close to the dosing time of flibanserin. Doing so can cause excessive drowsiness and decreases in blood pressure, which may lead to dizziness, lightheadedness, fainting, and accidental injury. Take flibanserin at bedtime to minimize the risk of these effects. It is recommended that you stop drinking alcohol at least two hours before taking flibanserin; otherwise, you should just skip the flibanserin dose that evening. Alcohol should not be consumed until at least the morning after taking flibanserin at bedtime. Because grapefruit juice can significantly increase the blood levels of flibanserin, you should also avoid the consumption of grapefruit and grapefruit juice during treatment. Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Take trientine on an empty stomach 1 hour before or 2 hours after a meal and at least one hour apart from any other food, drug, or milk. You may experience reduced absorption of trientine in the presence of food or milk. The capsules should be swallowed whole with water and should not be opened or chewed.

Mineral supplements or mineral-containing medications such as multivitamin with minerals can bind to trientine in the gastrointestinal tract, which may reduce the absorption of both trientine and the mineral. It is best to avoid taking these medications together when possible. However, if you must take both, you should try to separate the times of administration by at least two hours. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.