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Drug Interactions between Adderall and propafenone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

propafenone amphetamine

Applies to: propafenone and Adderall (amphetamine / dextroamphetamine)

Propafenone may increase the blood levels of amphetamine. This may increase the risk and/or severity of side effects such as nervousness, increased heart rate and/or blood pressure, loss of appetite, and circulation problems in your fingers and toes. Combining these medications can also increase the risk of seizures, especially if both medications are associated with an increased seizure risk. The risk of getting a rare but serious condition called serotonin syndrome, which has been seen with amphetamine, might also be increased. Symptoms of serotonin syndrome include confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

propafenone dextroamphetamine

Applies to: propafenone and Adderall (amphetamine / dextroamphetamine)

Propafenone may increase the blood levels of dextroamphetamine. This may increase the risk and/or severity of side effects such as nervousness, increased heart rate and/or blood pressure, loss of appetite, and circulation problems in your fingers and toes. Combining these medications can also increase the risk of seizures, especially if both medications are associated with an increased seizure risk. The risk of getting a rare but serious condition called serotonin syndrome, which has been seen with dextroamphetamine, might also be increased. Symptoms of serotonin syndrome include confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

propafenone food

Applies to: propafenone

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with propafenone as they may increase the blood levels of propafenone in some patients. This can cause serious side effects such as new or worsening irregular heart rhythm or heart failure; chest pain; difficulty breathing; fluid retention and swelling; and slow heart rate and pulse. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

amphetamine food

Applies to: Adderall (amphetamine / dextroamphetamine)

Using amphetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with amphetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

dextroamphetamine food

Applies to: Adderall (amphetamine / dextroamphetamine)

Using dextroamphetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with dextroamphetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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