Skip to Content

Drug interactions between Adderall and caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate

Results for the following 2 drugs:
Adderall (amphetamine/dextroamphetamine)
caffeine/pheniramine/phenylephrine/sodium citrate/sodium salicylate

Interactions between your drugs

Moderate

phenylephrine amphetamine

Applies to: caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate and Adderall (amphetamine / dextroamphetamine)

Both phenylephrine and amphetamine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

phenylephrine dextroamphetamine

Applies to: caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate and Adderall (amphetamine / dextroamphetamine)

Both phenylephrine and dextroamphetamine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

amphetamine sodium citrate

Applies to: Adderall (amphetamine / dextroamphetamine) and caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate

Ask your doctor before using amphetamine together with sodium citrate, this can increase the effects of amphetamine. Call the doctor if you experience restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safey use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

dextroamphetamine sodium citrate

Applies to: Adderall (amphetamine / dextroamphetamine) and caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate

Ask your doctor before using dextroamphetamine together with sodium citrate, this can increase the effects of dextroamphetamine. Call the doctor if you experience restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safey use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions

Moderate

amphetamine food

Applies to: Adderall (amphetamine / dextroamphetamine)

Using amphetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with amphetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

dextroamphetamine food

Applies to: Adderall (amphetamine / dextroamphetamine)

Using dextroamphetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with dextroamphetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

pheniramine food

Applies to: caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate

Alcohol can increase the nervous system side effects of pheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with pheniramine. Do not use more than the recommended dose of pheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Minor

caffeine food

Applies to: caffeine / pheniramine / phenylephrine / sodium citrate / sodium salicylate

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Stimulants

Therapeutic duplication

The recommended maximum number of medicines in the 'stimulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'stimulants' category:

  • amphetamine/dextroamphetamine
  • caffeine/pheniramine/phenylephrine/sodium citrate/sodium salicylate

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Duplication

Cerebral stimulants

Therapeutic duplication

The recommended maximum number of medicines in the 'cerebral stimulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'cerebral stimulants' category:

  • amphetamine/dextroamphetamine
  • caffeine/pheniramine/phenylephrine/sodium citrate/sodium salicylate

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide