Can you take Adagrasib with Sofpironium topical?
1 drug interaction and 3 additional warnings found for the following 2 drugs:
- adagrasib
- sofpironium topical
Drug interactions
Moderate drug interactions
Moderate:
adagrasib sofpironium topical
Applies to: adagrasib and sofpironium topical
Adagrasib may increase the blood levels of sofpironium topical.
High levels of sofpironium topical can increase the risk of side effects which include:
- blurred vision
- difficulty with urination
- heat intolerance
- dry mouth
Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
adagrasib Food/Lifestyle
Applies to: adagrasib
You should avoid consumption of grapefruit and grapefruit juice during approximately the first 8 days of treatment with adagrasib. During this time, grapefruit juice may increase the blood levels of adagrasib.
This may increase the risk of side effects such as:
- diarrhea
- fatigue
- musculoskeletal pain
- hepatotoxicity
- renal impairment
- an irregular heart rhythm that may be serious and potentially life-threatening
You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with adagrasib.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
2 potential interactions Applies to: 2 conditions, including Long QT Syndrome and Pulmonary Impairment.
Long QT Syndrome
Moderate:
adagrasib
Adagrasib has a moderate potential interaction with Long QT Syndrome.
Adagrasib can cause QTc prolongation, which increases the risk of ventricular tachyarrhythmias or sudden death. Use should be avoided in patients with congenital long QT syndrome, in patients with concurrent QTc prolongation, and patients taking other medicines known to prolong the QTc interval. Monitor ECG and electrolytes prior to starting treatment and as indicated during therapy.
Pulmonary Impairment
Moderate:
adagrasib
Adagrasib has a moderate potential interaction with Pulmonary Impairment.
Adagrasib can cause interstitial lung disease (ILD)/pneumonitis which can be fatal. Patients should be monitored for new or worsening symptoms indicative of ILD/pneumonitis during treatment. Caution is advised in patients with pulmonary impairment.
Report options
More resources
adagrasib
A total of 706 drugs are known to interact with adagrasib.
- Adagrasib is in the drug class miscellaneous antineoplastics.
- Adagrasib is used to treat Non Small Cell Lung Cancer.
sofpironium topical
A total of 202 drugs are known to interact with sofpironium topical.
- Sofpironium topical is in the drug class miscellaneous topical agents.
- Sofpironium topical is used to treat Hyperhidrosis.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.