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Drug Interactions between acyclovir and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

acyclovir probenecid

Applies to: acyclovir and probenecid

The coadministration of probenecid and acyclovir may result in elevated plasma concentrations of acyclovir. In 3 subjects with normal renal function, probenecid 1 gram increased the area under the plasma concentration-time curve and terminal plasma half-life of acyclovir (5 mg/kg intravenously) by an average of 40% and 18%, respectively. Renal clearance decreased an average of 32%. The mechanism is competitive inhibition of acyclovir renal tubular secretion by probenecid. Although this interaction is unlikely to be of clinical significance, caution may be advisable if acyclovir is used concomitantly with probenecid.

References (1)
  1. Laskin OL, de Miranda P, King DH, et al. (1982) "Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans." Antimicrob Agents Chemother, 21, p. 804-7

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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