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Drug Interactions between acyclovir and guaifenesin / oxtriphylline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

acyclovir oxtriphylline

Applies to: acyclovir and guaifenesin / oxtriphylline

Limited data suggest that the combination of a methyl xanthine with acyclovir may lead to elevated theophylline levels potentiating pharmacologic and adverse effects. The mechanism may be due to inhibition of theophylline oxidative metabolism. Clinical and laboratory monitoring is warranted if these agents are given concurrently. Patients receiving this combination should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References (1)
  1. Maeda Y, Konishi T, Omoda K, Takeda Y, Fukuhara S, Fukuzawa M, Ohune T, Tsuya T, Tsukiai S (1996) "Inhibition of theophylline metabolism by aciclovir." Biol Pharm Bull, 19, p. 1591-5

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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