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Drug Interactions between Actonel with Calcium and oxidronate

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

calcium carbonate risedronate

Applies to: Actonel with Calcium (calcium carbonate / risedronate) and Actonel with Calcium (calcium carbonate / risedronate)

ADJUST DOSING INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to interfere with the gastrointestinal absorption of oral bisphosphonates. For example, the bioavailability of tiludronate has been shown to decrease 80% during simultaneous administration with calcium, and 60% when aluminum- or magnesium-containing antacids were administered one hour before tiludronate.

MANAGEMENT: Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.

References (6)
  1. (2001) "Product Information. Fosamax (alendronate)." Merck & Co., Inc
  2. Darcy PF (1995) "Nutrient-drug interactions." Adverse Drug React Toxicol Rev, 14, p. 233-54
  3. "Product Information. Skelid (tiludronate)." Sanofi Winthrop Pharmaceuticals
  4. (2001) "Product Information. Actonel (risedronate)." Procter and Gamble Pharmaceuticals
  5. (2001) "Product Information. Bonefos (clodronate)." Rhone-Poulenc Rorer Canada Inc
  6. (2005) "Product Information. Boniva (ibandronate)." Roche Laboratories
Moderate

risedronate oxidronate

Applies to: Actonel with Calcium (calcium carbonate / risedronate) and oxidronate

MONITOR: Administration of technetium (Tc 99m) oxidronate after chelating agents, diphosphonates, tetracyclines, or iron containing drugs may reduce the quality of the scintigraphic procedure by decreasing the accumulation of Tc 99m oxidronate in skeletal bone. The exact mechanism of the interaction is unknown; however, it may be related to the effects of the interacting drugs on bone homeostasis.

MANAGEMENT: Proceed with caution if chelating agents, diphosphonates, tetracyclines, and iron-containing drugs are used prior to technetium (Tc 99m) oxidronate. The quality of the resulting imaging may be reduced.

References (7)
  1. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  2. (2018) "Product Information. TechneScan HDP (oxidronate)." Curium Pharmaceuticals
  3. (2023) "Product Information. Technescan HDP (oxidronate)." Landauer Radiopharmaceuticals Pty Ltd
  4. (2021) "Product Information. HDP (Radpharm) (oxidronate)." Global Medical Solutions Pty Limited t/a Radpharm Scientific
  5. (2023) "Product Information. Technescan HDP Kit (oxidronate)." Curium Pharma UK Ltd
  6. Warner AJ, Hathaway-Schrader JD, Lubker R, Davies C, Novince CM (2023) Tetracyclines and bone: unclear actions with potentially lasting effects. https://www.sciencedirect.com/science/article/abs/pii/S8756328222000539
  7. Balogh E, Paragh G, Jeney V (2023) Influence of iron on bone homeostasis. https://www.mdpi.com/1424-8247/11/4/107

Drug and food interactions

Moderate

calcium carbonate food

Applies to: Actonel with Calcium (calcium carbonate / risedronate)

ADJUST DOSING INTERVAL: Administration with food may increase the absorption of calcium. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption.

MANAGEMENT: Calcium may be administered with food to increase absorption. Consider withholding calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid.

References (6)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  3. Cerner Multum, Inc. "Australian Product Information."
  4. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  5. Mangels AR (2014) "Bone nutrients for vegetarians." Am J Clin Nutr, 100, epub
  6. Davies NT (1979) "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc, 38, p. 121-8
Moderate

risedronate food

Applies to: Actonel with Calcium (calcium carbonate / risedronate)

ADJUST DOSING INTERVAL: Food significantly decreases the bioavailability of risedronate, possibly to negligible levels.

MANAGEMENT: Risedronate should be administered with 180 to 240 mL (6 to 8 ounces) of plain water, at least 30 minutes before the first food, beverage, or medication of the day. Patients should remain upright for at least 30 minutes following administration of risedronate.

References (1)
  1. (2001) "Product Information. Actonel (risedronate)." Procter and Gamble Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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