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Drug Interactions between acetaminophen / aspirin and Tecfidera

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

aspirin dimethyl fumarate

Applies to: acetaminophen / aspirin and Tecfidera (dimethyl fumarate)

The use of dimethyl fumarate in combination with higher doses of aspirin, such as those used to relieve pain and inflammation, may increase the potential for kidney damage. Let your doctor know if you experience any signs or symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and/or irregular heart rhythm. You can also speak with your healthcare provider to see if an alternative pain reliever, such as acetaminophen, might be an option for you.

Lower doses of non-enteric coated aspirin (up to 325 mg) are sometimes taken about 30 minutes prior to dimethyl fumarate to help reduce the occurrence and severity of flushing. This combination has not been evaluated for longer than 4 weeks. Let your doctor know if you experience any side effects that are particularly bothersome or do not improve during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

acetaminophen food

Applies to: acetaminophen / aspirin

Ask your doctor before using acetaminophen together with ethanol (alcohol). This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

aspirin food

Applies to: acetaminophen / aspirin

Ask your doctor before using aspirin together with ethanol (alcohol). Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

dimethyl fumarate food

Applies to: Tecfidera (dimethyl fumarate)

Information for this minor interaction is available on the professional version.

Minor

aspirin food

Applies to: acetaminophen / aspirin

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.