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Drug Interactions between Accretropin and macimorelin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

somatropin macimorelin

Applies to: Accretropin (somatropin) and macimorelin

GENERALLY AVOID: Drugs that may blunt the growth hormone response to macimorelin such as muscarinic antagonists (e.g., atropine), anti-thyroid agents (e.g., propylthiouracil), and growth hormone products may impact the accuracy of the macimorelin diagnostic test.

MANAGEMENT: Concomitant use of drugs that can blunt the response to macimorelin should generally be avoided. A sufficient washout period following discontinuation of these drugs is recommended prior to macimorelin administration. The prescribing information recommends discontinuing growth hormone products for at least one week before administering the macimorelin diagnostic test.

References

  1. "Product Information. Macrilen (macimorelin)." Aeterna Zentaris (2018):

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Drug and food interactions

Moderate

macimorelin food

Applies to: macimorelin

ADJUST DOSING INTERVAL: Food reduces the oral bioavailability of macimorelin. According to the product labeling, administration with a liquid meal decreased macimorelin peak plasma concentration (Cmax) and systemic exposure (AUC) by 55% and 49%, respectively, compared to administration under fasting conditions (i.e., for at least 8 hours).

MANAGEMENT: Macimorelin should be administered after fasting for at least 8 hours.

References

  1. "Product Information. Macrilen (macimorelin)." Aeterna Zentaris (2018):

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Growth hormones

Therapeutic duplication

The recommended maximum number of medicines in the 'growth hormones' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'growth hormones' category:

  • Accretropin (somatropin)
  • macimorelin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer