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Drug Interactions between Acclean and allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen topical

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

chlorhexidine topical allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen

Applies to: Acclean (chlorhexidine topical) and allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen topical

GENERALLY AVOID: Topical agents such as mafenide acetate, chlorhexidine, and silver-containing antimicrobials may impair the integrity and/or viability of allogeneic cultured keratinocytes and dermal fibroblasts. The mechanism of interaction has not been described. Mafenide acetate has been shown to decrease keratinocyte viability and disrupt the integrity of tissue-engineered human skin substitutes containing NIKS(R) keratinocytes or primary keratinocytes. In addition, chlorhexidine solution has been shown to be toxic to keratinocytes and human dermal fibroblasts. Similarly, in vitro data suggest silver-containing antimicrobials may decrease the viability of keratinocytes and human dermal fibroblasts.

MANAGEMENT: Use of topical agents such as mafenide acetate, chlorhexidine, or silver-containing antimicrobials is not recommended following application of allogeneic cultured keratinocytes and dermal fibroblasts.

References (1)
  1. (2021) "Product Information. StrataGraft (allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen)." Stratatech Corporation

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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