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Drug Interactions between acalabrutinib and famotidine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

famotidine acalabrutinib

Applies to: famotidine and acalabrutinib

The following interaction applies only if you are receiving the capsule formulation of acalabrutinib (Calquence), but not the tablet formulation:

By reducing the acidity level in the stomach, famotidine may interfere with absorption of the medication in acalabrutinib capsules and reduce its effectiveness. This interaction has not been shown to occur with the tablet formulation. You should generally take acalabrutinib capsules at least two hours before famotidine. Most antacids (but not medications that suppress acid production such as ranitidine (Zantac), famotidine (Pepcid), nizatidine or cimetidine) may also be taken two hours after a dose of acalabrutinib capsules. Talk to your doctor or pharmacist if you have questions on how to take acalabrutinib and other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

acalabrutinib food

Applies to: acalabrutinib

Acalabrutinib may be taken with or without food. However, consumption of grapefruit and grapefruit juice can increase the blood levels of acalabrutinib. This may increase side effects such as nausea, vomiting, diarrhea, abdominal pain, hemorrhage, development of other cancers, abnormal heart rhythm, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You should avoid the consumption of grapefruit and grapefruit juice during treatment with acalabrutinib. Be sure to take the medication at approximately the same time(s) every day to maintain consistent blood levels and effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

famotidine food

Applies to: famotidine

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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