Drug Interactions between acalabrutinib and Alka-Seltzer Original

Using acalabrutinib together with aspirin may increase the risk of bleeding. In clinical studies, treatment with acalabrutinib alone has been associated with severe and sometimes fatal hemorrhage. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions such as monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; a severe headache; and/or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using sodium bicarbonate together with aspirin may decrease the effects of aspirin. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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The following interaction applies only if you are receiving the capsule formulation of acalabrutinib (Calquence), but not the tablet formulation:

By reducing the acidity level in the stomach, sodium bicarbonate may interfere with absorption of the medication in acalabrutinib capsules and reduce its effectiveness. This interaction has not been shown to occur with the tablet formulation. You should generally take acalabrutinib capsules at least two hours before sodium bicarbonate. Most antacids (but not medications that suppress acid production such as ranitidine (Zantac), famotidine (Pepcid), nizatidine or cimetidine) may also be taken two hours after a dose of acalabrutinib capsules. Talk to your doctor or pharmacist if you have questions on how to take acalabrutinib and other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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