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Drug Interactions between abiraterone and treprostinil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

treprostinil abiraterone

Applies to: treprostinil and abiraterone

MONITOR: Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations of treprostinil, which is primarily metabolized by the isoenzyme. Coadministration of the potent CYP450 2C8 inhibitor gemfibrozil (600 mg twice daily) with oral treprostinil (treprostinil diolamine) in healthy adults resulted in a doubling of both the systemic exposure (AUC) and peak plasma concentration (Cmax) of treprostinil. However, it has not been determined if the safety and efficacy of treprostinil administered parenterally (e.g., subcutaneously, intravenously, via inhalation) are altered by this interaction.

MANAGEMENT: Pharmacologic response to treprostinil should be monitored more closely whenever a CYP450 2C8 inhibitor is added to or withdrawn from therapy, and the treprostinil dosage adjusted as necessary. Patients starting on oral treprostinil who are already on a CYP450 2C8 inhibitor should use a lower starting dose of 0.125 mg twice daily and titrate in 0.125 mg twice daily increments, not more frequently than every 3 to 4 days. If a CYP450 2C8 inhibitor is started during therapy with treprostinil, patients should be advised to notify their physician if they experience excessive adverse effects of treprostinil such as headache, dizziness, lightheadedness, flushing, diarrhea, edema, and unusual bleeding or bruising. Abrupt cessation of a CYP450 2C8 inhibitor should be avoided where possible due to the potential of worsening pulmonary arterial hypertension symptoms.

References

  1. (2002) "Product Information. Remodulin (treprostinil)." United Therapeutics Corporation
  2. (2023) "Product Information. Treprostinil (treprostinil)." Sandoz Inc
  3. (2022) "Product Information. Tyvaso (treprostinil)." United Therapeutics Corporation
  4. (2023) "Product Information. Treposuvi (treprostinil)." AOP Orphan Ltd
  5. (2023) "Product Information. Orenitram (treprostinil)." United Therapeutics Corporation
View all 5 references

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Drug and food interactions

Moderate

abiraterone food

Applies to: abiraterone

ADJUST DOSING INTERVAL: Food may significantly increase the oral bioavailability of some formulations of abiraterone acetate. Compared to administration in the fasted state, abiraterone peak plasma concentration (Cmax) and systemic exposure (AUC) were approximately 7- and 5-fold higher, respectively, when a single dose of abiraterone acetate was administered with a low-fat meal (7% fat; 300 calories) and approximately 17- and 10-fold higher, respectively, when it was administered with a high-fat meal (57% fat; 825 calories). Given the normal variation in the content and composition of meals, taking abiraterone acetate with meals has the potential to result in increased and highly variable exposures. The safety of these increased exposures during multiple dosing has not been assessed. However, the abiraterone acetate 125 mg tablet, commonly marketed as Yonsa, was found to have an approximately 6.5-fold higher Cmax and 4.4-fold higher AUC when a single dose of 500 mg (4 tablets) was administered with a high-fat meal (56% - 60% fat, 900 - 1000 calories) compared to overnight fasting in healthy volunteers. These differences were not considered clinically significant for this formulation.

MANAGEMENT: Some formulations of abiraterone acetate must be taken on an empty stomach. No food should be consumed for at least two hours before and one hour after the abiraterone acetate dose. However, the abiraterone acetate 125 mg tablet, commonly marketed as Yonsa, can be taken with or without food. The manufacturer's product labeling should be consulted for specific guidance.

References

  1. (2011) "Product Information. Zytiga (abiraterone)." Centocor Inc
  2. (2023) "Product Information. Akeega (abiraterone-niraparib)." Janssen Biotech, Inc.
  3. (2023) "Product Information. Akeega (abiraterone-niraparib)." Janssen Inc
  4. (2021) "Product Information. Zytiga (abiraterone)." Janssen Biotech, Inc.
  5. (2022) "Product Information. Yonsa (abiraterone)." Sun Pharmaceutical Industries
  6. (2023) "Product Information. Apo-Abiraterone (abiraterone)." Apotex Inc
  7. (2021) "Product Information. Zytiga (abiraterone)." Janssen-Cilag Pty Ltd
  8. (2023) "Product Information. Abiraterone (abiraterone)." Wockhardt UK Ltd
  9. (2023) "Product Information. Yonsa Mpred (abiraterone-methylprednisolone)." Sun Pharma ANZ Pty Ltd
View all 9 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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