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Drug Interactions between abciximab and Gentran 40 with 0.9% Sodium Chloride

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

dextran, low molecular weight abciximab

Applies to: Gentran 40 with 0.9% Sodium Chloride (dextran, low molecular weight) and abciximab

CONTRAINDICATED: The risk of bleeding is increased when dextran and abciximab are administered concurrently. In the EPIC trial, 5 of 11 patients who received low molecular weight dextran, abciximab, and oral anticoagulants developed major bleeding and 4 of 11 had minor bleeding events, while there were no bleeding events in 5 patients who received placebo and dextran.

MANAGEMENT: The use of dextran before percutaneous coronary intervention (PCI) or intent to use it during PCI is considered contraindicated by the manufacturer of abciximab.

References (1)
  1. (2001) "Product Information. ReoPro (abciximab)." Lilly, Eli and Company

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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