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Drug Interactions between abatacept and tocilizumab

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

abatacept tocilizumab

Applies to: abatacept and tocilizumab

GENERALLY AVOID: Coadministration of interleukin-6 (IL-6) inhibitors with other biologic disease-modifying antirheumatic drugs (DMARDs) may result in increased immunosuppression and a greater risk of infection. Treatment with IL-6 inhibitors has been associated with serious, potentially life-threatening and fatal infections, including tuberculosis, invasive fungal infections such as candidiasis, aspergillosis and pneumocystis, and other opportunistic infections. Cases have occurred mostly in patients receiving concomitant immunosuppressants like methotrexate or corticosteroids. Use of IL-6 inhibitors in combination with biologic DMARDs such as tumor necrosis factor (TNF) blockers, IL-1R antagonists, anti-CD20 monoclonal antibodies, or T-cell costimulation modulators has not been studied. There may be an increased risk of neutropenia and infections during treatment with IL-6 inhibitors in patients who were previously exposed to TNF antagonists.

MANAGEMENT: Concomitant use of IL-6 inhibitors with other biologic DMARDs should be avoided.

References (9)
  1. (2001) "Product Information. Remicade (infliximab)." Centocor Inc
  2. (2001) "Product Information. Enbrel (etanercept)." Wyeth-Ayerst Laboratories
  3. (2003) "Product Information. Humira (adalimumab)." Abbott Pharmaceutical
  4. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  5. Cerner Multum, Inc. "Australian Product Information."
  6. (2008) "Product Information. Cimzia (certolizumab)." UCB Pharma Inc
  7. (2009) "Product Information. Simponi (golimumab)." Centocor Inc
  8. (2010) "Product Information. Actemra (tocilizumab)." Genentech
  9. (2017) "Product Information. Kevzara (sarilumab)." sanofi-aventis

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Biologic dmards

Therapeutic duplication

The recommended maximum number of medicines in the 'biologic DMARDs' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'biologic DMARDs' category:

  • abatacept
  • tocilizumab

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer