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Drug Interactions between A-Cillin and Benefiber (guar gum formulation)

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

guar gum penicillin V potassium

Applies to: Benefiber (guar gum formulation) (guar gum) and A-Cillin (penicillin v potassium)

GENERALLY AVOID: Concurrent administration of guar gum may decrease the plasma levels of orally administered penicillins by reducing their absorption. In a study of 10 healthy volunteers administered phenoxymethyl penicillin with and without guar gum, both the peak serum concentration and the area under the serum concentration-time curve of penicillin were found to be significantly reduced by the gum.

MANAGEMENT: The use of guar gum should preferably be avoided during oral penicillin therapy. If these agents must be used together, separating the times of administration by as much as possible may help but has not been studied.

References

  1. Huupponen R, Seppala P, Iisalo E (1984) "Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man." Eur J Clin Pharmacol, 26, p. 279-81
  2. Fugh-Berman A (2000) "Herb-drug interactions." Lancet, 355, p. 134-8

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Drug and food interactions

Moderate

guar gum food

Applies to: Benefiber (guar gum formulation) (guar gum)

ADJUST DOSING INTERVAL: Bulk-forming laxatives such as guar gum, psyllium, polycarbophil, or methylcellulose may affect the bioavailability of concomitantly administered substances due to their effect on the rate of gastrointestinal transit and gastric emptying.

MANAGEMENT: In general, oral medications should be administered at least 2 hours before or 2 hours after dosing of the bulk-forming laxative.

References

  1. (2001) "Product Information. Metamucil (psyllium)." Procter and Gamble Pharmaceuticals

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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