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Drug Interactions between 5-HTP and vilazodone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

5-hydroxytryptophan vilazodone

Applies to: 5-HTP (5-hydroxytryptophan) and vilazodone

GENERALLY AVOID: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 5-HT2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: In general, the concomitant use of tryptophan and agents with serotonergic activity such as serotonin reuptake inhibitors should be avoided. If concomitant use is considered clinically necessary, caution and close monitoring for signs and symptoms of serotonin syndrome is recommended, particularly at treatment initiation and during any dosage increases. Patients should be instructed to seek immediate medical attention if they develop any signs or symptoms of serotonin syndrome. The product labeling for each serotonergic medication as well as any relevant guidelines should also be consulted for specific recommendations.

References (17)
  1. (2001) "Product Information. Zoloft (sertraline)." Roerig Division
  2. (2001) "Product Information. Prozac (fluoxetine)." Dista Products Company
  3. (2001) "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories
  4. (2001) "Product Information. Paxil (paroxetine)." GlaxoSmithKline
  5. (2001) "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc
  6. (2001) "Product Information. Celexa (citalopram)." Forest Pharmaceuticals
  7. (2004) "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company
  8. (2008) "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories
  9. (2009) "Product Information. Savella (milnacipran)." Forest Pharmaceuticals
  10. (2009) "Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals
  11. (2011) "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC
  12. (2013) "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals
  13. (2013) "Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America
  14. (2023) "Product Information. Escitalopram (Apo) (escitalopram)." Arrotex Pharmaceuticals Pty Ltd
  15. (2024) "Product Information. Escitalopram (escitalopram)." Milpharm Ltd
  16. (2024) "Product Information. Escitalopram Oxalate (escitalopram)." Aurobindo Pharma USA Inc
  17. (2024) "Product Information. ACH-Escitalopram (escitalopram)." Accord Healthcare

Drug and food interactions

Moderate

vilazodone food

Applies to: vilazodone

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of vilazodone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of vilazodone. According to the product labeling, vilazodone blood concentrations in the fasted state can be decreased by approximately 50% compared to the fed state, which may result in diminished effectiveness in some patients. The absolute bioavailability of vilazodone is 72% with food. In study subjects, administration with food (high-fat or light meal) increased vilazodone peak plasma concentration (Cmax) by approximately 147% to 160% and systemic exposure (AUC) by approximately 64% to 85%.

MANAGEMENT: Patients receiving vilazodone should be advised to avoid consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how vilazodone affects them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. Vilazodone should be taken with food. Administration without food may result in inadequate drug concentrations and diminished effectiveness.

References (1)
  1. (2011) "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Miscellaneous antidepressants

Therapeutic duplication

The recommended maximum number of medicines in the 'miscellaneous antidepressants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'miscellaneous antidepressants' category:

  • 5-HTP (5-hydroxytryptophan)
  • vilazodone

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer