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Radiogardase Disease Interactions

There are 3 disease interactions with Radiogardase (prussian blue).

Moderate

Prussian blue (applies to Radiogardase) constipation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction

Prussian blue insoluble is not absorbed through the intact gastrointestinal wall and its clearance depends on the gastrointestinal tract transit time. Prussian blue can decrease gastrointestinal motility and slow the transit time of the agent in the gastrointestinal tract and increase the radiation absorbed. Also, the use of prussian blue can cause constipation. Care is recommended in patients with disorders associated with decreased gastrointestinal motility as these patients are at higher risk and should be carefully monitored.

References

  1. (2022) "Product Information. Radiogardase (Prussian blue)." Heyl Chemisch Pharmaceuticals
Moderate

Prussian blue (applies to Radiogardase) electrolyte abnormalities

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias

The use of prussian blue may decrease electrolytes found in the gastrointestinal tract. Hypokalemia has been reported with the use of prussian blue, and this might be more pronounced in patients with preexisting cardiac arrhythmias or electrolyte imbalances. It is recommended to closely monitor these patient's serum electrolytes levels during therapy with this agent.

References

  1. (2022) "Product Information. Radiogardase (Prussian blue)." Heyl Chemisch Pharmaceuticals
Moderate

Prussian blue (applies to Radiogardase) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Prussian blue insoluble binds cesium and thallium isotopes in the gastrointestinal tract after these isotopes are ingested or excreted in the bile by the liver. Prussian blue does not rely on hepatic metabolism. Its clearance from the body depends on the gastrointestinal tract transit time. Prussian blue may be less effective in patients with liver disease due to decreased excretion of cesium and thallium in the bile. Care should be exercised when using this agent in patients with hepatic impairment.

References

  1. (2022) "Product Information. Radiogardase (Prussian blue)." Heyl Chemisch Pharmaceuticals

Radiogardase alcohol/food interactions

There is 1 alcohol/food interaction with Radiogardase (prussian blue).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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