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Biltricide (praziquantel) Disease Interactions

There are 4 disease interactions with Biltricide (praziquantel):

Major

Praziquantel (Includes Biltricide) ↔ Cysticercosis

Severe Potential Hazard, High plausibility

Applies to: Cysticercosis

Since parasite destruction within the eye can cause irreparable lesions, ocular cysticercosis should not be treated with praziquantel.

References

  1. "Product Information. Biltricide (praziquantel)." Bayer, West Haven, CT.
  2. Bada JL, Trevino B, Cabezos J "Convulsive seizures after treatment with praziquantel." Br Med J (Clin Res Ed) 296 (1988): 646
  3. Markwalder K, Hess K, Valavanis A, Witassek F "Cerebral cysticercosis: treatment with praziquantel. Report of two cases." Am J Trop Med Hyg 33 (1984): 273-80
  4. Leblanc R, Knowles KF, Melanson D, MacLean JD, Rouleau G, Farmer JP "Neurocysticercosis: surgical and medical management with praziquantel." Neurosurgery 18 (1986): 419-27
  5. Flisser A, Madrazo I, Plancarte A, Schantz P, Allan J, Craig P, Sarti E "Neurological symptoms in occult neurocysticercosis after single taeniacidal dose of praziquantel." Lancet 342 (1993): 748
View all 5 references
Major

Praziquantel (Includes Biltricide) ↔ Epilepsy

Severe Potential Hazard, Moderate plausibility

Applies to: Seizures

Praziquantel can exacerbate central nervous system pathology due to schistosomiasis. As a general rule this drug should not be administered in individuals with a history of epilepsy or seizures and any other signs of potential central nervous system involvement such as subcutaneous nodules suggestive of cysticercosis.

Moderate

Praziquantel (Includes Biltricide) ↔ Arrhythmias

Moderate Potential Hazard, Moderate plausibility

Applies to: Arrhythmias

Patients suffering from cardiac irregularities such as arrhythmias should be monitored during treatment with praziquantel.

Moderate

Praziquantel (Includes Biltricide) ↔ Liver Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Caution should be exercised when administering praziquantel at the usual recommended doses in patients with moderate to severe liver impairment (Child Pugh class B and C). Reduced metabolism of praziquantel may lead to considerably higher and longer lasting plasma concentrations of the unmetabolized drug.

Biltricide (praziquantel) drug Interactions

There are 77 drug interactions with Biltricide (praziquantel)

Biltricide (praziquantel) alcohol/food Interactions

There is 1 alcohol/food interaction with Biltricide (praziquantel)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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