Konakion Disease Interactions
There is 1 disease interaction with Konakion (phytonadione).
Phytonadione (vit. K) (applies to Konakion) hepatobiliary dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Biliary Obstruction
Phytonadione is fat soluble and requires bile for adequate intestinal absorption. Biliary dysfunction decreases the absorption of phytonadione. Phytonadione is metabolized by the liver and excreted in bile and urine. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of phytonadione. Phytonadione will not correct hypoprothrombinemia due to hepatocellular dysfunction or damage and administration of excessive phytonadione may worsen hepatic function.
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Konakion drug interactions
There are 11 drug interactions with Konakion (phytonadione).
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- Drug class: anticoagulant reversal agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Aquamephyton
Aquamephyton is used for hypoprothrombinemia, anticoagulant induced, hypoprothrombinemia, not ...
Mephyton
Mephyton is used for hypoprothrombinemia, anticoagulant induced, hypoprothrombinemia, not ...
Further information
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